Jul 3

Platelet-Rich Plasma Injections Delay the Need for Knee Arthroplasty

TOBI Faculty Dr. Diego Delgado and colleagues recently published an article in International Orthopedics.  A retrospective study and survival analysis, researchers seek to evaluate the ability of PRP injections to delay the progression of Knee OA and, thereby, delay the use of total knee arthroplasty to treat advanced knee osteoarthritis. This study looks at the outcomes from two points-of-view: the time of delay, and the percentage of patients foregoing surgery. Patients who underwent knee replacement surgery between 2014 - 2019...

Jun 23

Chemical Profile and Clinical Efficacy of Micro-Fragmented Adipose-derived MSC Therapy in the Treatment of Knee Osteoarthritis

Check out the new article by long-time TOBI faculty, Dr. Gerard Malanga, published in Biologic Orthopedic Journal. By the year 2040, it is estimated that 25% of adults in the US will be diagnosed with osteoarthritis by a physician.  Osteoarthritis, considered as a progessive joint disorder due to “wear and tear,” has been described by researchers to involve a complex dynamic of pro-inflammatory mediators leading to an increase of enzymes that degrade soft-tissue supporting the joint. This article looks at...

Mar 10

Leukocyte-rich PRP for Knee Osteoarthritis: Current Concepts. 

Osteoarthritis is one of the most debilitating degenerative conditions affecting more than a third of the population of active individuals over the age of 65. Upon onset of clinical manifestations, osteoarthritis (OA) may become increasingly destructive regarding disease progression with respect to the microenvironment. Investigations into the leukocyte concentration in PRP formulations and its effect on the healing process in OA has created some controversy in evidence-based practice. It is well known that the inflammatory phase is integral to the...