Jun 5

Cellular and Clinical Analyses of Autologous Bone Marrow Aspirate Injection for Knee OA

Congratulations to TOBI Alum Drs. Gregory Lutz and Nicholas Beatty for their contributions to the PM&R journal on the cellular and clinical analysis of autologous bone marrow aspirate (BMA) injections to treat Knee Osteoarthritis. This prospective observational pilot study looks at the effects of the cellular content in BMA on articular cartilage in patients with mild knee osteoarthritis. Ten patients were included in the overall analysis.  BMA was aspirated from the iliac crest under fluoroscopy or  ultrasound-guide techniques. The main...

Jan 14

Bone Marrow Aspirate Concentrate (BMAC) May Support Bone Decompression Therapy in the Treatment of Osteonecrosis

Osteonecrosis of the femoral head commonly affects patients between the age of 30 to 50 years and can lead to degeneration of the hip joint. A number of risk factors have been identified, including trauma to the hip joint, long-term use of corticosteroids, alcoholism, smoking, and more recently, organ transplantation, HIV infection, and autoimmune disease. 70-90% of cases regarding osteonecrosis of the femoral head have been reported to collapse with five years of a severe diagnosis, thus early-stage intervention is...

Mar 8

Amniotic Fluid Products Probably Don’t Contain Stem Cells, but May Still Modulate Healing

In vivo amniotic fluid is known to contain growth factors and mesenchymal stem cells (MSCs), which prior research has suggested may aid in tissue healing. Several companies have injectable amniotic fluid products  (AFPs) on the market based on this  prior research, but it’s unclear exactly what the composition of these AFPs is and whether they contain viable MSCs that could participate in healing. To clarify these lingering questions, upcoming TOBI conference speaker Dr. Panero and several of his colleagues at...