TOBI Faculty Publications: March 2018

Apr 11

TOBI Faculty Publications: March 2018

Below is a resource of all March 2018 regenerative medicine publications authored by TOBI Speakers and Faculty, including alumni faculty. Each month, we compile a list with links and brief summaries of all new research and studies to keep TOBI community members informed and on the cutting edge of regenerative medicine research. Studies are listed alphabetically by TOBI Faculty names.

If you are a TOBI Faculty member or alumni and would like your publications included in the TOBI monthly publications blog, please send it to

27 March 2018
Can Competitive Athletes Return to High-Level Play After Osteochondral Allograft Transplantation of the Knee?
This review, by TOBI Faculty Brian J. Cole, MD, was completed with the purpose of investigating functional outcomes among competitive athletes undergoing osteochondral allografts (OCA) transplantation of the knee, including rates of return to play (RTP), and factors preventing RTP.
See the full study here.


07 March 2018
Orthopaedic Journal of Sports Medicine
Male Sex, Decreased Activity Level, and Higher BMI Associated With Lower Completion of Patient-Reported Outcome (PRO) Measures Following ACL Reconstruction
Dr. Brian Cole, in another March publication, evaluates whih variables are associated with compliance with completing PRO surveys in patients who have undergone anterior cruciate ligament reconstruction (ACLR).
See the full study here.


01 March 2018
Current Reviews in Musculoskeletal Medicine
The Role of Biologic Therapy in Rotator Cuff Tears and Repairs
The purpose of this review, by TOBI Faculty Brian J. Cole, MD, was to establish the foundation of the major biologic adjuvants to rotator cuff repairs and review recent scientific findings. Platelet-rich plasma (PRP) overall has no significant impact on functional outcomes and repair integrity, but may be more advantageous in small to medium tears. Further studies should focus on leukocyte-rich versus poor preparations and the use of PRP in patients that are high risk for repair failure. Biologic and synthetic patches or augments provide mechanical stability for large and massive rotator cuff tears and decrease re-tear rates. Mesenchymal stem cells have demonstrated improved healing rates without an impact on outcomes. Cytokines and growth factors show promise in animal models, but require human trials to further evaluate. In massive or revision repairs, allograft or synthetic patch augmentation should be considered. Platelet-rich plasma may have benefit in smaller tears. Further studies are needed to evaluate the value of mesenchymal stem cells and various cytologic chemical signals.
See the full study here.


27 March 2018
International Orthopedics
Subchondral stem cell therapy versus contralateral total knee arthroplasty for osteoarthritis following secondary osteonecrosis of the knee
Total knee arthroplasty (TKA) implanted in patients with secondary osteonecrosis (ON) related to corticosteroids have relatively poor outcome (20% revision rate) at a mean follow-up of only eight years. TOBI Faculty Alumni Dr. Philippe Hernigou (et al) hypothesized that subchondral bone marrow injection might improve knees in these patients.
See the full study here.


08 March 2018
British Medical Bulletin
The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review
Longtime TOBI Faculty Dr. William Murrell completed this systematic review of the effectiveness of prolotherapy in knee Osteoarthritis. OA often leads to symptoms such as pain, stiffness and decreased function. OA is treated with a wide range of modalities, both conservatively and surgically. Prolotherapy has been used to treat various musculoskeletal problems and has shown some promise. Searches of the electronic databases, PubMed, ISI web of science, PEDro and SPORTDiscus, were conducted for all Level 1-4 studies published from inception through to December 2016. Ten studies were evaluated and results show significant improvement in scores for pain, function and range of motion, both in the short term and long term.
See the full study here.


25 March 2018
Journal of Orthopaedic Research
Enhancing Integration of Articular Cartilage Grafts via Photochemical Bonding
The integration of osteochondral grafts to native articular cartilage is critical as the lack of graft integration may lead to poor load transfer and nutrient transport and continued tissue degradation. Photochemical bonding promotes graft integration by activating a photosensitizer at the interface via a light source and avoids negative effects associated with other bonding techniques. In this study, TOBI Faculty Jasn Dragoo, MD, hypothesized that the bond strength depends on photosensitizer type and concentration and light exposure.
See the full study here.


05 March 2018
Editorial Commentary: Paving a Road Requires a Well-Mixed Cement Stem Cells, Platelet-Rich Plasma, and Shoulder Rotator Cuff Healing
The process of healing in musculoskeletal tissues is complex, and the addition of devices, including platelet-rich plasma and mesenchymal stem cells, to biologically enhance it may favor its optimization. This work shows in a compelling fashion that it is possible to produce the right admixture of physical and biological factors to make it happen in rotator cuff repair.
See the full commentary here.

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