TOBI Faculty Publications: February 2018

Mar 22

TOBI Faculty Publications: February 2018

Below is a resource of all February 2018 regenerative medicine publications authored by TOBI Speakers and Faculty, including alumni faculty. Each month, we compile a list with links and brief summaries of all new research and studies to keep TOBI community members informed and on the cutting edge of regenerative medicine research. Studies are listed alphabetically by TOBI Faculty names.

If you are a TOBI Faculty member or alumni and would like your publications included in the TOBI monthly publications blog, please send it to

01 Feb 2018
The American Journal of Sports Medicine
Video Analysis of Anterior Cruciate Ligament Tears in Professional American Football Athletes
Anterior cruciate ligament (ACL) injuries are prevalent in contact sports that feature cutting and pivoting, such as American football. These injuries typically require surgical treatment, can result in significant missed time from competition, and may have deleterious long-term effects on an athlete’s playing career and health. While the majority of ACL tears in other sports have been shown to occur from a noncontact mechanism, it stands to reason that a significant number of ACL tears in American football would occur after contact, given the nature of the sport.: The purpose of this study, by TOBI Faculty Brian Cole, MD, was to describe the mechanism, playing situation, and lower extremity limb position associated with ACL injuries in professional American football players through video analysis to test the hypothesis that a majority of injuries occur via a contact mechanism.
See the full study here.


09 Feb 2018
Orthopaedic Journal of Sports Medicine
Clinical Outcomes After Microfracture of the Knee: Midterm Follow-up
Microfracture is a single-stage arthroscopic procedure used to treat small- and medium-sized cartilage defects, the clinical results of which have been mixed to date. The purpose of this study, also by Brian J. Cole, MD, is to retrospectively evaluate prospectively collected patient-reported outcomes (PROs) after microfracture as well as to determine patient-related and defect-related factors associated with clinical outcomes and which factors predict the need for additional surgery.
See the full study here.


02 Feb 2018
Orthopaedic journal of sports medicine
Synovial Fluid Lubricant Properties are Transiently Deficient after Arthroscopic Articular Cartilage Defect Repair with Platelet-Enriched Fibrin Alone and with Mesenchymal Stem Cells
Following various types of naturally-occurring traumatic injury to an articular joint, the lubricating ability of synovial fluid is impaired, with a correlated alteration in the concentration and/or structure of lubricant molecules, hyaluronan and proteoglycan-4. However, the effect of arthroscopic cartilage repair surgery on synovial fluid lubricant function and composition is unknown. The hypothesis of this study, by TOBI Faculty Alumni Wayne McIlwraith, DVM, PhD, is that arthroscopic treatment of full-thickness chondral defects in horses with (1) platelet-enriched fibrin or (2) platelet-enriched fibrin+mesenchymal stem cells leads to equine synovial fluid with impaired lubricant function and hyaluronan and proteoglycan-4 composition.
See the full study here.


26 Feb 2018
Journal of Foot and Ankle Research
Higher frequency of hamstring injuries in elite track and field athletes who had a previous injury to the ankle – a 17 years observational cohort study

Inversion injury to the ankle and hamstring injuries are common problems in most sports. It is not known whether these injuries constitute a predisposing factor or a precursor of injury or re-injury of these anatomical locations. TOBI Faculty Alumni Nicola Maffulli, MD, PhD, wished to test the hypothesis that a previous inversion ankle injury exerted a significant effect on the chance of an athlete suffering from a subsequent ipsilateral hamstring injury and vice versa.
See the full study here.


22 Feb 2018
Journal of Orthopaedic Research

Mitoprotective Therapy Preserves Chondrocyte Viability and Prevents Cartilage Degeneration in an Ex Vivo Model of Posttraumatic Osteoarthritis

No disease-modifying osteoarthritis (OA) drugs are available to prevent posttraumatic osteoarthritis (PTOA). Mitochondria (MT) mediate the pathogenesis of many degenerative diseases, and recent evidence indicates that MT dysfunction is a peracute (within minutes to hours) response of cartilage to mechanical injury. The goal of this study was to investigate cardiolipin-targeted mitoprotection as a new strategy to prevent chondrocyte death and cartilage degeneration after injury. This study, by TOBI Faculty Lisa Fortier, PhD, DVM, is the first investigation of cardiolipin-targeted mitoprotective therapy in cartilage. These results suggest that even when treatment is delayed by up to 12 h after injury, mitoprotection may be a useful strategy in the prevention of PTOA.
See the full study here.


12 Feb 2018
Progress in the Use of Dental Pulp Stem Cells in Regenerative Medicine
The field of tissue engineering is emerging as a multidisciplinary area with promising potential for regenerating new tissues and organs. This approach requires the involvement of three essential components: stem cells, scaffolds and growth factors. To date, dental pulp stem cells have received special attention because they represent a readily accessible source of stem cells. The present review, by TOBI Faculty Eduardo Anitua, MD, DDS, PhD, aims to describe the current knowledge of dental pulp stem cells, considering in depth the key aspects related to the characterization, establishment, maintenance and cryopreservation of primary cultures and their involvement in the multilineage differentiation potential. The main clinical applications for these stem cells and their combination with several biomaterials is also covered.
See the full study here.


08 Feb 2018
PM&R: The Journal of Injury, Function, and Rehabilitation
Ultrasound-Guided Percutaneous Needle Tenotomy for Chronic Tensor Fascia Lata Tendinopathy: A Case Series and Description of Sonographic Findings
Proximal tensor fascia lata tendinopathy at its origin on the anterior superior iliac crest is one potential cause of lateral hip pain. However, there is limited literature regarding the mechanism, disease course, or management of this condition. There is growing evidence supporting the effective treatment of percutaneous needle tenotomy (PNT) for chronic tendinopathy. Only a single case series has examined the efficacy of PNT for tendinopathy about the hip and pelvis. Presented here by TOBI Faculty Kenneth Mautner, MD, are examples of 2 cases of chronic recalcitrant proximal ultrasound confirmed tensor fascia lata (tendinopathy effectively treated with ultrasound-guided PNT.
See the full study here.


28 Feb 2018
Science Translational Medicine
In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs
More than 2 million bone-grafting procedures are performed each year using autografts or allografts. However, both options carry disadvantages, and there remains a clear medical need for the development of new therapies for massive bone loss and fracture nonunions. The authors, including TOBI alumni Hyun Bae, MD, hypothesized that localized ultrasound-mediated, microbubble-enhanced therapeutic gene delivery to endogenous stem cells would induce efficient bone regeneration and fracture repair. To test this hypothesis, they surgically created a critical-sized bone fracture in the tibiae of Yucatán mini-pigs, a clinically relevant large animal model.
See the full study here.

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