Vertebral Intraosseous Plasma Rich in Growth Factor (PRGF) Infiltrations as a Novel Strategy for the Treatment of Lumbar Pathology
TOBI Faculty, Dr. Kirchner and colleagues, have recently published their case presentation of a novel strategy for the treatment of degenerative low back pain in a recent issue of the Journal of Orthopedic Surgery and Research. A primary motivation to adopt minimally invasive cell-based therapies in the field of Orthobiologics to treat degenerative conditions of the spine led this team of researchers and clinicians to present the first reported case description of the utilization of Vertebral Interosseous and Intervertebral disc infiltrations of leukocyte-free PRP. The technique was adapted from previous published clinical applications of combined intra-articular and intraosseous PRP infiltrations in patients with knee and hip osteoarthritis for the treatment of chronic pain. In a recent publication, Dr. Kirchner and colleagues present a clinical case of a 40-year old man with a 10-year history of chronic low back pain that was unalleviated by conventional methods of pain management. Clinical findings upon evaluation showed several spinal alterations indicative of degeneration and herniation. The patient underwent a series of three treatments, two of which were intraosseous infiltrations performed in a operating room and the third dose being administered to the paravertebral lamina in an adapted out-patient operating room
In brief summary, disc and endplate regions of the lumbar spine present functional units susceptible to degeneration. Spontaneous regression of disc herniation is widely known, but the mechanism of regression is poorly understood. Dr. Kirchner and colleagues provide evidence-based clinical results showing aspects of disc degeneration being reversed by the use of an entirely autologous platelet-rich plasma system that mimics the physiological repair process through the release of growth factors in PRGF infiltrations.
We congratulate TOBI Faculty, Dr. Kirschner on the success of a novel strategy, which is published in the Journal of Orthopedic Surgery and Research. Read the article here.