TOBI Faculty Publications: November 2017

Mar 5

TOBI Faculty Publications: November 2017

Below is a resource of all November 2017 regenerative medicine publications authored by TOBI Speakers and Faculty, including alumni faculty. Each month, we compile a list with links and brief summaries of all new research and studies to keep TOBI community members informed and on the cutting edge of regenerative medicine research. Studies are listed alphabetically by TOBI Faculty names.

If you are a TOBI Faculty member or alumni and would like your publications included in the TOBI monthly publications blog, please send it to


6 Nov 2017
Three-Year Follow-up of the Prospective, Randomized, Controlled Trial of Coflex Interlaminar Stabilization vs Instrumented Fusion in Patients With Lumbar Stenosis
This is a report by TOBI Faculty alumni Hyun Bae of the 36-month follow-up analysis of the coflex Interlaminar Stabilization after decompression, examined under a FDA investigational device exemption clinical trial, intended to provide stabilization after decompression while preserving normal segmental motion at the treated level.
See the full study here.


15 Nov 2017
The American Journal of Sports Medicine
Do Outcomes of Osteochondral Allograft Transplantation Differ Based on Age and Sex? A Comparative Matched Group Analysis
Brian Cole, MD, et al, set out here to assess whether patient age or sex has an effect on outcomes after osteochondral allograft transplantation. Results showed that osteochndral allograft transplantation is a safe and reliable treatment option for osteochondral defects in patients aged ≥40 years. Male and female patients had similar outcomes. Patients aged <40 years demonstrated lower KOOS symptom subscores postoperatively compared with older patients.
See the full study here.


20 Nov 2017
LMWF-5A for the Treatment of Severe Osteoarthritis of the Knee: Integrated Analysis of Safety and Efficacy
In this study by TOBI Faculty Brian Cole, MD, et al., the low-molecular-weight fraction of 5% human serum albumin (LMWF-5A) is evaluated in its efficacy to treat the signs and symptoms of severe osteoarthritis of the knee.
See the full study here.


28 Nov 2017
Does Treatment of the Tibia Matter in Bipolar Chondral Defects of the Knee? Clinical Outcomes with Greater Than Two Years Follow-Up
Dr. Brian Cole publishes on ostechondral allograft (OCA) outcomes again this month with a study comparing OCA outcomes of bipolar defects with isolated femoral defects and to investigate the optimal treatment of bipolar defects by comparing femral OCA with tibial debridement to femoral OCA and tibial microfracture.
See the full study here.


02 Nov 2017
The Influence of Full-Thickness Chondral Defects on Outcomes Following Meniscal Allograft Transplantation: A Comparative Study
In yet another November publication, TOBI 2018 Faculty Brian Cole, MD, compares patients who underwent meniscus allograft transplantation (MAT) with full-thickness chondral defects (FTD) with those with no chondral defect. Cole and authors compared these two sets of patients with regard to the following areas: change in patient-reported outcomes (PROs) from baseline to 2-year follow-up and baseline to the final follow-up (including comparisons to minimal clinically important differences), complications and complication rates, reoperations and reoperation rates/timing, and failures and time to failure (revision MAT or conversion to total knee arthroplasty).
See the full study here.


13 Nov 2017
International Orthopaedics
Single-stage treatment of infected tibial non-unions and osteomyelitis with bone marrow granulocytes precursors protecting bone graft
Infected non-unions present a clinical challenge, especially with risk of recurrent infection. Bone marrow contains granulocyte precursors identified in vitro as colony forming units-granulocyte macrophage (CFU-GM) have a prophylactic action against infection. The authors, including TOBI Faculty alumni Dr. Phillippe Hernigou, tested the hypothesis that bone marrow concentrated granulocytes precursors added to a standard bone graft could decrease the risk of recurrence of infection when single-stage treatment of infected tibial non-unions is performed with bone graft.
See the full study here.


08 Nov 2017
American journal of veterinary research
Antigenicity of mesenchymal stem cells in an inflamed joint environment
Longtime TOBI Speaker Lisa Fortier, DVM, PhD, carried this study out to determine whether major histocompatability complex (MHC) class II expression in equine mesenchymal stem cells (MSCs) changes with exposure to a proinflammatory environment reflective of an inflamed joint.
See the full study here.


14 Nov 2017
The Journal of Bone and Joint Surgery: American Volume
What’s New in Orthopaedic Rehabilitation
The goal of rehabilitation medicine is to restore function in individuals with disability. This update, by TOBI 2018 Faculty William Murrell, MD presents evidence from studies published from March 2016 to February 2017 in the area of orthopaedic rehabilitation. Articles from the American Journal of Physical Medicine & Rehabilitation, The American Journal of Sports Medicine, Archives of Physical Medicine and Rehabilitation, The BMJ, The Clinical Journal of Pain, JAMA, The Journal of Bone & Joint Surgery, The Journal of Pain, the Journal of Shoulder and Elbow Surgery, The New England Journal of Medicine, Pain Medicine, Physical Therapy, PM&R, and Spine were considered.
See the full study here.


09 Nov 2017
Rheumatic diseases clinics of North America
Imaging of Inflammatory Arthritis in Adults: Status and Perspectives on the Use of Radiographs, Ultrasound, and MRI
The term inflammatory arthritis encompasses a variety of conditions featuring synovial inflammation as a defining characteristic, with resultant local tissue damage occurring over time. These arthritides often share overlapping clinical and imaging characteristics (examined here by faculty alumni Hollis Potter,) although the pattern of joint involvement, specific appearance of pathologic changes, and associated findings often allow imaging-based differentiation or individual arthritides.
See the full study here.


01 Nov 2017
The American Journal of Sports Medicine
Intra-articular Mesenchymal Stem Cell Therapy for the Human Joint: A Systematic Review
Stem cell therapy is emerging as a potential treatment of osteoarthritis (OA) and chondral defects (CDs). However, there is a great deal of heterogeneity in the literature. The indications for stem cell use, the ideal tissue source, and the preferred outcome measures for stem cell-based treatments have yet to be determined. Dr. Thomas Vangsness et al. seek to provide clinicians with a comprehensive overview of the entire body of the current human literature investigating the safety and efficacy of intra-articular mesenchymal stem cell (MSC) therapy in all joints.
See the full study here.

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