TOBI Faculty Publications: October 2017

Nov 7

TOBI Faculty Publications: October 2017

1 Oct 2017
The American Journal of Sports Medicine
Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial
The purpose of this study, by TOBI Faculty Alumni Peter Verdonk, MD, is to investigate if one intra-articular injection of autologous protein solution (APS) can reduce pain and improve function in patients affected by knee OA in a multicenter, randomized, double-blind, saline-controlled study. This study provides evidence to support the safety and clinical improvement at 1-year follow-up of a single intra-articular injection of APS in patients affected by knee OA.
See the full study here.


12 Oct 2017
Cell Death & Disease
Impairment of PTX3 Expression in Osteoblasts: A Key Element for Osteoporosis.
Dr. Nicola Maffulli, who spoke at TOBI 2017, contributed to this study investigating the treatment of human osteoblasts. Pentraxin 3 (PTX3) is a multifunctional glycoprotein regulating inflammatory response, cell proliferation and migration and deposition and remodelling of the extracellular matrix by a variety of cells. The authors investigated the possible role of PTX3 in bone homeostasis. Results showed that treatment of human osteoblast primary cultures derived from young patients with anti-PTX3 antibody dramatically affected osteoblast behavior. Altogether, these results suggest a central role of PTX3 in bone homeostasis showing its involvement in osteoblast proliferation, differentiation and function.
See the full study here:


16 Oct 2017
Journal of the American Veterinary Medical Association
Treatment of Medial Shoulder Joint Instability in Dogs by Extracapsular Stabilization with a Prosthetic Ligament: 39 cases (2008-2013)
Longtime TOBI Speaker Dr. Sherman Canapp, DVM, published this study in the Journal of the American Veterinary Medical Association investigating clinical outcomes for dogs surgically treated for medial shoulder joint instability (MSI) by extracapsular stabilization with a prosthetic ligament. Results showed that surgical treatment of MSI in dogs by extracapsular stabilization with a prosthetic ligament was associated with a complication rate considered acceptable for orthopedic procedures. All patient outcomes were considered successful.
See the full study here.


16 Oct 2017
Physical Medicine and Rehabilitation Clinics of North America
Musculoskeletal Injuries and Regenerative Medicine in the Elderly Patient
Regenerative medicine has gained increasing popularity in its clinical applications, particularly in the field of musculoskeletal medicine. Regenerative medicine, a broad term, can be thought of as a particular medical strategy that strives to rebuild and restore diseased tissue to normal physiologic tissue baseline. Simply put, regenerative strategies augment the body’s innate physiology to heal pathologic processes. This article, by TOBI Speaker & Faculty Alumni John Cianca, MD focuses on specific regenerative strategies and the uses of them for common pathologies in the aging adult, including platelet-rich plasma, mesenchymal stem cells, viscosupplementation, and prolotherapy.
See the full study here.


24 Oct 2017
Stem Cells Translational Medicine Journal
Allogeneic Stem Cells Alter Gene Expression and Improve Healing of Distal Limb Wounds in Horses.
Distal extremity wounds are a significant clinical problem in horses and humans and may benefit from mesenchymal stem cell (MSC) therapy.  TOBI Faculty Alumni Jamie Textor, Phd, DVM, evaluates evaluated the effects of direct wound treatment with allogeneic stem cells, in terms of gross, histologic, and transcriptional features of healing. She concluded that MSC therapy shows promise for distal extremity wounds in horses, particularly when applied by direct injection into the wound margin.
See the full study here.


27 Oct 2017
Journal of Cosmetic Dermatology
The Effect of Plasma Rich in Growth Factors Combined with Follicular Unit Extraction Surgery for the Treatment of Hair Loss: A Pilot Study
The aim of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGF) technology as an adjuvant therapy for FUE surgery in hair loss affected patients. Along with co-authors, TOBI Alumni Eduardo Anitua’s preliminary data demonstrates that PRGF is able to minimize the postsurgical follicle loss and potentiate the performance of grafted hairs. The fibrin clot not only acts as a protective barrier against environmental factors, but also provides a biologically active scaffold that induces resident cell proliferation and maintains an optimal integrity of the grafted hair.
See the full study here.


30 Oct 2017
The Open Orthopaedics Journal
Chronic Achilles Tendon Rupture
Nicola Maffulli, MD, MS, PhD, published this review article about diagnosis and management of chronic Achilles tendon ruptures. Minimally invasive Achilles tendon reconstruction is discussed. Maffulli and co-authors conclude that the management of chronic ruptures is more demanding than acute tears, because of the retraction of the tendon ends, and the gap makes primary repair impossible. Wound complications and infections are frequent after open procedures. Minimally invasive treatments provide good functional results and lower complications rate.
See the full study here.


30 Oct 2017
The Regulatory Review
How the FDA Should Use Its Authority to Regulate Stem Cells
TOBI 2017 Speaker Andrew Ittleman, JD, has published a valuable article on how the FDA should regulate human cells. This article, which appeared in The Regulatory Review, provides a brief history of the FDA’s involvement in the regulation of human cells, starting with the Wall Street Journal Op-ed, “The FDA Wants to Regulate Your Cells“, written by Scott Gottlieb in 2012. Gottlieb is now the Commissioner of the FDA. Ittleman analyzes Gottlieb’s political history regarding the regulation of human cells, as well as FDA’s, and delivers legal predictions regarding what regulations the FDA will roll out this fall, in addition to what it should.
See the full article here.

Above is a resource of all October 2017 regenerative medicine publications authored by TOBI Speakers and Faculty, including alumni faculty. Each month, we compile a list with links and brief summaries of all new research and studies to keep TOBI community members informed and on the cutting edge of regenerative medicine research. Studies are listed alphabetically by TOBI Faculty names.

If you are a TOBI Faculty member or alumni and would like your publications included in the TOBI monthly publications blog, please send it to

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