February 2017: TOBI Faculty Publications in Regenerative Medicine

Mar 9

February 2017: TOBI Faculty Publications in Regenerative Medicine

Below is a resource of all February 2017 regenerative medicine publications authored by TOBI Speakers and Faculty, including alumni faculty. Each month, we compile a list with links and brief summaries of new research and studies to keep  TOBI community members informed and on the cutting edge of regenerative medicine research. Studies are listed alphabetically by TOBI Faculty names.

If you are a TOBI Faculty member or alumni and would like your publication included in the TOBI monthly publications blog, please email us: info@tobiconference.com

20 Feb 2017; Pain Physician Journal
Platelet-Rich Plasma Therapy and Antithrombotic Drugs.
TOBI Faculty alumni Eduardo Anitua authored this response to the publication “Timing of Platelet Rich Plasma Injections During Antithrombotic Therapy.” Anitua emphasized the necessity “to deepen the study of PRP patients medicated with antithrombotic drugs, both at pre-clinical and clinical levels. Hence, a better understanding of the molecular mechanisms underlying the effectiveness of PRP will be the keystone to extend this treatment to patients with antithrombotic therapy.”
See the full study here.

21 Feb 2017; Dermatologic Surgery: The Official Publication for the American Society for Dermatologic Surgery
The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study
Autologous growth factors have proved to promote tissue regeneration in various medical fields. This study, by TOBI Faculty Eduardo Anitua, looks into the role of PRP (platelet-rich plamas) in hair follicle restoration. The objective of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGFs) for the treatment of androgenetic alopecia (AGA). Patients declared an overall positive satisfaction, and a high clinical improvement score was achieved when comparing premacrophotographs and postmacrophotographs. Although randomized clinical trials are needed, this study provides preliminary data supporting the positive therapeutic effect of autologous growth factors on hair follicle regeneration.
See the full study here.

10 Feb 2017; Journal of Biomedical Materials Research
Balancing microbial and mammalian cell functions on calcium ion-modified implant surfaces.
In this work, Eduardo Anitua, MD, analyzed classical microrough implant surfaces and a new calcium-ion-modified implant surface in terms of soft- and hard-tissue integration, bacterial adhesion, and biofilm formation. Their results highlight the importance of a calcium-rich hydrated interface to favor mammalian cell functions over microbial colonization at implant surfaces.
See the full study here.

February 14, 2017; Seminars in cancer biology
Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases
Eduardo Anitua, MD, of the Biotechnology Institute (BTI) of Vitoria, Spain, published this study on cellular acidification as a new approach to cancer treatment. During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopathogenesis to treatment. The abnormalities of intracellular alkalinization along with extracellular acidification of all types of solid tumors and leukemic cells have never been described in any other disease and now appear to be a specific hallmark of malignancy. As a consequence of this intracellular acid-base homeostatic failure, the attempt to induce cellular acidification using proton transport inhibitors and other intracellular acidifiers of different origins is becoming a new therapeutic concept and selective target of cancer treatment, both as a metabolic mediator of apoptosis and in the overcoming of multiple drug resistance (MDR). Importantly, there is increasing data showing that different ion channels contribute to mediate significant aspects of cancer pH regulation and etiopathogenesis. Finally, we discuss the extension of this new pH-centric oncological paradigm into the opposite metabolic and homeostatic acid-base situation found in human neurodegenerative diseases (HNDDs), which opens novel concepts in the prevention and treatment of HNDDs through the utilization of a cohort of neural and non-neural derived hormones and human growth factors.
See the full study here.

Online 1 Feb 2017; Stem cells translational medicine
The 3Rs of Cell Therapy
The 3Rs for a good education are “reading, ‘riting, and ‘rithmetic.” The basis for good health care solutions for the emergent field of cell therapy in the future will also involve 3Rs: regulation, reimbursement, and realization of value. TOBI 2017 Speaker Arnold Caplan, Phd, reviews these three Rs in relation to the business models in this new field of cell therapy. This article brings forth realities facing this new industry for its approaches to provide curative health care solutions.
See the full study here.

23 Feb 2017; Journal of computer assisted tomography
Procedure-Oriented Torsional Anatomy of the Hand for Spasticity Injection
The purpose of this publication, authored in part by TOBI Faculty John Cianca, MD, is to provide musculoskeletal ultrasound (MSKUS) images of hand anatomy in the position of hemiparetic flexion as a reference for spasticity injections. There presently is no anatomic reference in the literature for these spastic postures. This study is part three of a series examining torsional anatomy of the body. The authors hope this series of images will increase the accuracy, safety, and efficacy of spasticity injections in the hand.
See the full study here.

24 Feb 2017, American Journal of Orthopedics
Rates of Deep Vein Thrombosis Occurring After Osteotomy About the Knee
TOBI Faculty Brian J. Cole, MD conducted a study to determine the rates of symptomatic deep vein thrombosis (DVT) and pulmonary embolism (PE) after high tibial osteotomy (HTO), distal femoral osteotomy (DFO), or tibial tubercle osteotomy (TTO) in patients who did not receive postoperative chemical prophylaxis.
See the full study here.

6 Feb 2017; Journal of Shoulder and Elbow Surgery
Midterm results of osteochondral allograft transplantation to the humeral head
This study, by longtime TOBI Faculty member Brian Cole, MD evaluated clinical outcomes of osteochondral allograft (OCA) transplantation for humeral head osteochondral defects.
See the full study here.

1 Feb 2017; The American Journal of Sports Medicine
Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis
This study compared the use of platelet-rich plasma (PRP) for the treatment of osteoarthritis when compared with hyaluronic acid (HA), an accepted nonsurgical treatment for symptomatic OA. TOBI Faculty members Lisa A Fortier, DVM, PhD, and Brian J. Cole, MD, published this comparison in his study, which involved a total of 111 patients. The purpose of this study was to compare the clinical and biological effects of an intra-articular injection of PRP with those of an intra-articular injection of HA in patients with mild to moderate knee OA.
See the full study here.

17 Feb 2017; Orthopaedic Journal of Sports Medicine
Research Productivity of Sports Medicine Fellowship Faculty
Research productivity is considered an important factor in academic advancement in sports medicine. No study to date has evaluated academic productivity and correlates of academic rank for sports medicine fellowship faculty, until this one, authored again by TOBI Faculty Brian J. Cole, MD. A total of 90 AOSSM sports medicine fellowship programs with 610 associated faculty members were identified. Faculty were predominantly male (94%), at academic medical centers (74%), members of AOSSM (71%), and sports medicine-fellowship trained (84%). Faculty had a median of 18 (range, 0-684) publications overall, including a median of 3 (range, 0-161) publications since 2012.
See the full study here.

17 Feb 2017; Orthopaedic Journal of Sports Medicine
Biologic Approaches for the Treatment of Partial Tears of the Anterior Cruciate Ligament: A Current Concepts Review.
Anterior cruciate ligament reconstruction (ACLR) has been established as the gold standard for treatment of complete ruptures of the anterior cruciate ligament (ACL) in active, symptomatic individuals. In contrast, treatment of partial tears of the ACL remains controversial. Biologically augmented ACL-repair techniques are expanding in an attempt to regenerate and improve healing and outcomes of both the native ACL and the reconstructed graft tissue. The purpose of this literature review, by TOBI Faculty Ignacio Dallo, MD, is to review the biologic treatment options for partial tears of the ACL.
See the full study here.

1 Feb 2017; American Journal of Sports Medicine
 of the Female Athlete Triad Risk Assessment Stratification to the Development of Bone Stress Injuries in Collegiate Athletes.
The female athlete triad (referred to as the triad) contributes to adverse health outcomes, including bone stress injuries(BSIs), in female athletes. Guidelines were published in 2014 for clinical management of athletes affected by the triad. This study, by TOBI 2017 Faculty Michael Fredericson, MD, aimed to (1) classify athletes from a collegiate population of 16 sports into low-, moderate-, and high-riskcategories using the Female Athlete Triad Cumulative Risk Assessment score and (2) evaluate the predictive value of the risk categories for subsequent BSIs.
See the full study here.

12 Feb 2017; Skeletal Radiology
Ultrasound evaluation of bursae: anatomy and pathological appearances
TOBI Faculty Jonathan Jacobson, MD, completed this full ultrasound evaluation of bursae. A bursa is an extra-articular sac that may communicate with a joint and functions to decrease friction between tendons and either bone or skin. Bursae can be classified as native and non-native (adventitious) bursae. This article reviews the anatomical locations of common bursae and shows pathological examples using ultrasound. Knowledge of typical locations and imaging appearances of bursae can aid in narrowing the differential diagnosis and guiding further management and treatment decisions.
See the full study here.

22 Feb 2018; Oxford University Press: Pain Medicine
Increased Nuclear T2 Signal Intensity and Improved Function and Pain in a Patient One Year After an Intradiscal Platelet–Rich Plasma Injection
Dr. Gregory Lutz of the Hospital for Special Surgery continues his remarkable research on intradiscal platelet-rich plasma (PRP) injections in this new publication in the Oxford University Press’ Pain Medicine. Dr. Lutz will be discussing and teaching his research further at TOBI 2017, both at the Symposium podium and in the workshop & hands-on cadaver lab.
See the full study here.

27 Feb 2017; Orthopedics
Characteristics of Orthopedic Publications in High-Impact General Medical Journals
Orthopedic studies are occasionally published in high-impact general medical journals; these studies are often given high visibility and have significant potential to impact health care policy and inform clinical decision-making. The purpose of this review, by TOBI Faculty alumni Robert Marx, MD, was to investigate the characteristics of operative orthopedic studies published in high-impact medical journals. The number of orthopedic studies published in high-impact medical journals is relatively low; however, these studies demonstrate methodological characteristics that may bias toward nonoperative treatment. Careful analysis and interpretation of orthopedic studies published in these journals is warranted
See the full study here.

7 Feb 2017; The Musculoskeletal Journal of the Hospital for Special Surgery
Comparison of Revision Rates of Non-modular Constrained Versus Posterior Stabilized Total Knee Arthroplasty: a Propensity Score Matched Cohort
TOBI Faculty alumni Robert Marx, MD, published this article on different options for attaining stability during total knee arthoplasty (TKA). Although traditional constrained total knee prostheses have generally been used in conjunction with intramedullary stems, some devices have been widely used without the use of stems, referred to as non-modular constrained condylar total knee arthroplasty (NMCCK). The aim of this study was to compare revisions rates after total knee replacement with a non-modular constrained condylar total knee (NMCCK) compared to a posterior-stabilized (PS) design.
See the full study here.

16 Feb 2017; Journal of the American Veterinary Medical Association
Effects of sensor position on kinematic data obtained with an inertial sensor system during gait analysis of trotting horses.
TOBI Faculty alumni Wayne McIlwraith, DVM, works in this publication to determine the effects of altering location of right forelimb and pelvic sensors on kinematic data obtained with a commonly used inertial sensor system during gait analysis of trotting horses. He studied 12 horses with mild to moderate lameness of at least 1 hind limb, with or without lameness of the forelimbs. Results of this study indicated that a 2-cm change in the location of the pelvic sensor during kinematic gait analysis had a significant effect on hind limb kinematic data of the system used. Therefore, placement of this sensor needs to be anatomically accurate.
See the full study here.

22 Feb 2017; Pain Physician Journal
Responsible, Safe, and Effective Prescription of Opioids for Chronic Non-Cancer Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines
Longtime TOBI faculty, and director of the TOBI 2017 Interventional Spine Lab Annu Navani, MD, published this important set of guidelines for the prescription of opioids for the management of chronic non-cancer pain. The purpose of this set of ASIPP guidelines is to develop a consistent philosophy among the many diverse groups with an interest in opioid use as to how appropriately prescribe opioids, to improve the treatment of chronic non-cancer pain and to reduce the likelihood of drug abuse and diversion. These guidelines are intended to provide a systematic and standardized approach to this complex and difficult arena of practice, while recognizing that every clinical situation is unique. The literature pertaining to opioid use, abuse, effectiveness, and adverse consequences was reviewed, with a best evidence synthesis of the available literature, and utilized grading for recommendation as described by the Agency for Healthcare Research and Quality (AHRQ).
See the full study here.

7 Feb 2017; The Musculoskeletal Journal of Hospital for Special Surgery
Commercial Separation Systems Designed for Preparation of Platelet-Rich Plasma Yield Differences in Cellular Composition
The role of platelet-rich plasma (PRP) in the treatment of sport-related injuries is unclear, largely due to the heterogeneity of clinical results. In this study, Kristin Oliver, MD, TOBI 2017 Speaker and Faculty, aims to compare the composition of PRP produced with five different commercially available systems, focusing on cellular concentrations and pH. Aside from platelet concentration and capture efficiency, significant compositional differences were identified between preparation systems. Caution should be employed when interpreting clinical results of studies utilizing PRP, as the role of compositional differences and their effect on outcome are unknown. Further study is necessary to determine the clinical significance of these differences.
See the full study here.

16 Feb 2017; Orthopaedic Journal of Sports Medicine
Acute Gastrocnemius-Soleus Complex Injuries in National Football League Athletes
This study was published by TOBI Faculty alumni Hollis Potter, MD, Radiology and Imaging Chair at the Hospital for Special Surgery. Lower extremity muscle injuries are common in professional football. Although less common than hamstring or quadriceps injuries in National Football League (NFL) athletes, calf injuries occur with relative frequency and have not previously been studied. This study evaluates gastrocnemius-soleus complex muscle injuries over the past 13 years from a single NFL team to determine the incidence of such injuries, their imaging characteristics, and return to play after such injuries and any correlation between imaging findings and prolonged return to play.
See the full study here.

24 Feb 2017; American Journal of Orthopedics
Precision and Accuracy of Identification of Anatomical Surface Landmarks by 30 Expert Hip Arthroscopists
TOBI Faculty alumni Jason Snibbe, MD, conducted this study to assess 30 expert hip arthroscopists’ ability to identify common surface landmarks used during hip arthroscopy. An ultrasonographer performed a musculoskeletal ultrasound examination and applied labels as well, and a photographer documented the examiner labels after obtaining overhead and lateral digital images with use of fixed camera mounts. Examiner labels demonstrated the highest potential for injury because of anterior portal inaccuracy. Expert hip arthroscopists varied in their ability to accurately and precisely identify common surface landmarks about the hip, using only manual palpation.
See the full study here.

14 Feb 2017; Journal of Magnetic Resonance Imaging
Diffusion tensor imaging of the anterior cruciate ligament graft
A great need exists for objective biomarkers to assess graft healing following ACL reconstruction to guide the time of return to sports. The purpose of this study was to evaluate the feasibility and reliability of diffusion tensor imaging (DTI) to delineate the anterior cruciate ligament (ACL) graft and to investigate its diffusion properties using a clinical 3T scanner. With his co-authors, TOBI Faculty alumni Peter Verdonk, MD, PhD, demonstrated the feasibility and reliability of DTI for the visualization and quantitative evaluation of the ACL graft at 3T.
See the full study here


For the latest orthobiologics research and best practices from global field leaders, join us at TOBI 2017:

The Orthobiologic Institute (TOBI)
7th Annual PRP & Regenerative Medicine Symposium with Workshops & Cadaver Labs (TOBI 2017)
June 8-10, 2017
Wynn, Las Vegas, NV


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